About Instil Bio
Instil Bio is a cell therapy company developing tumor infiltrating lymphocytes (TIL) for the treatment of solid tumor cancers. TIL are a patient’s own T cells harvested from the patient’s tumor, which are then expanded and reinfused into the patient to target and kill cancer cells. Instil is advancing its proprietary TIL manufacturing expertise, technology, and data into clinical trials, including a planned registrational study with its lead candidate and a first-in-human study of its next-generation engineered TIL. The company is led by world-class cell therapy experts and backed by premier global institutional investors.
Instil Bio UK is Instil’s rapidly growing, Manchester UK-based subsidiary. Our Manchester subsidiary has significant R&D, process development, and clinical manufacturing capabilities, with approximately 35 staff expanding to > 100 staff. Instil Bio UK has been generating cell therapy products for patient use since 2011, including TIL products and external partner genetically engineered T cell products.
The MSAT Team
The MSAT team is a new and critical function within Instil Bio UK – the scientists in this team operate as our cGMP process stewards. By developing a deep scientific understanding of the manufacturing process, the MSAT Scientists support the manufacture and release of safe and effective product.
We now have several opportunities for MSAT Scientists and Senior Scientists to join our team and contribute to delivering a right-sized, risk-based, lean approach to commercial TIL manufacture.
How You Will Contribute
The MSAT Team has multi-disciplinary influence with interactions across all operational functions of the business as well as regulatory agencies. As a member of this team your focus will be diverse, including elements of managing, implementing and executing:
• Tech Transfers to allow clinical manufacture
• Process Validation to ensure appropriately validated processes
• Process Troubleshooting to resolve manufacturing issues
• Process Improvements to improve process efficiency and reduce variability
• Process Monitoring to ensure all process data is appropriately captured
• Mentoring and coaching of technical and operations personnel
• Root Cause Investigations to ensure root causes are appropriately identified and resolved
• Deviation Impact Assessments to ensure robust and consistent approach
• Process Risk Assessments to ensure risks are appropriately identified and mitigated
• Change Controls to ensure appropriate changes are implemented
• Laboratory Investigations to contribute to Root Cause determination
As a Senior Scientist – MSAT you will be over-seeing and leading many of these activities.
What We Want You To Bring To The Team
In order to be successful as a Scientist/Senior Scientist – MSAT, you will be qualified to at least Degree level in a relevant scientific or technical discipline. You will be able to demonstrate outstanding communication skills together with a natural aptitude for proactive problem solving and troubleshooting. You will have specific experience of some or all of the following:
• Process validation
• Technical transfer
• Technical report writing
• cGMP in a biopharmaceutical manufacturing facility
• Statistical analysis of biopharmaceutical manufacturing process data
• Deviation Impact Assessments
• Root cause investigations
• Aseptic Processing
• Cell Culture
• Regulatory agency interaction
To be considered as a Senior Scientist – MSAT you will likely have significant experience over-seeing, implementing, and managing many of the above activities.
The Personal Opportunity
As we progress through clinical stages to commercialisation the challenge for the MSAT team is achieving process excellence through strong positive technical leadership; influencing and shaping such that changes can occur by bringing colleagues and departments with us.
If you are the type of scientist or engineer that thrives on a challenge and you want to join us on the journey from Clinical Stages to Commercialisation – enhancing your expertise in the developing Cell Therapy field – then this is definitely an opportunity for you. And we’ll be delighted to hear from you.
Remuneration & Benefits
The salary for the Scientist/Senior Scientist – MSAT will be competitive within the Biotechnology and wider Scientific Sector with actual salary offered reflecting relevant qualifications and experience as well as performance at interview. In any event we anticipate a basic salary in the £42,000 to £55,000 range, offered together with an attractive bonus and benefits package.
If you would like to join us as a Scientist/Senior Scientist – MSAT at this critical time in our development and you think your skills and experience are a good fit for this role, apply with a current CV and we’ll get back to you within a day or two.
If you would like to find out more about Instil Bio UK and our roadmap – there is plenty of opportunity for an informal fact-finding chat once you make your application.