Clinical Tissue Culture Specialists

About Instil Bio

Instil Bio is a cell therapy company developing tumor infiltrating lymphocytes (TIL) for the treatment of solid tumor cancers. TIL are a patient’s own T cells harvested from the patient’s tumor, which are then expanded and reinfused into the patient to target and kill cancer cells. Instil is advancing its proprietary TIL manufacturing expertise, technology, and data into clinical trials, including a planned registrational study with its lead candidate and a first-in-human study of its next-generation engineered TIL. The company is led by world-class cell therapy experts and backed by premier global institutional investors.

Instil Bio UK is Instil’s rapidly-growing, Manchester UK-based subsidiary. Our Manchester subsidiary has significant R&D, process development, and clinical manufacturing capabilities, with approximately 35 staff expanding to > 100 staff. Instil Bio UK has been generating cell therapy products for patient use since 2011, including TIL products and external partner genetically engineered T cell products.

Clinical Tissue Culture Specialists

We are seeking a two tissue recovery specialists to join the Process Development team at our Manchester site.  You will utilise Instil’s state of the art process to collect and disaggregate primary human tumours for clinical, Process Development & Research functions within the company.

The position will require you to be comfortable with coordinating and collecting tumour samples from patients undergoing routine surgery as part of their standard of care treatment.

Additionally, you will interface with several internal departments to ensure the intake of different tumour types meets the needs of each function.

You will work closely with line management to ensure training & practices are kept up to date with developing procedures used in the clinical setting.

Key Responsibilities Include (but not limited to):

TIL Recovery Process:

  • Tumour Preparation (Includes trimming, weighing, packaging tumour tissue & training of clinical site staff to perform Tumour Preparation steps)
  • Tumour Digestion (Addition of Media and Equipment process initiation)
  • Tumour Cryopreservation (Addition of Cryoprotectant and Freezing of Tumour Tissue)

Record Management:

  • Keep records up to date to comply with HTA and research ethics documentation
  • Maintain inventory human samples, logging intake and use in particular research applications

Supporting the Process Development Team:

  • Perform small scale production of TIL in a GLP-like environment, using complex equipment to analyse of processed tumours.
  • Continual improvement initiatives to increase operational efficiency of the laboratory
  • Coordinate with R&D team at a separate research site for the distribution of cryopreserved samples for research
  • Adhere to Instil Bio Health and Safety Regulations to and comply with Health and Safety Regulations & associated COSHH and Risk Assessments

For Clinical Samples:

  • Biomedical packaging, labelling, shipping LN2 shippers
  • Data input into the Instil Bio Clinical Logistics Portal
  • Maintain Tumour Procurement Hub per HTA requirements in regard to:
    • Personnel
    • Procedures
    • Facilities
    • Environmental Controls and Monitoring
    • Equipment
    • Supplies and Reagents
    • Recovery
    • Labelling Controls
    • Records Maintenance and Appropriate Tracking

Relevant Education Skills and Experience

To be successful as the Clinical Tissue Culture Specialist it is envisaged that you will have the following skills and experiences:

  • Aseptic cell culture technique
  • Good organisation, communication skills and attention to detail
  • Willingness to learn and apply new skills and techniques
  • Experience of working within a group whilst also maintaining individual responsibility for tasks assigned
  • Knowledge of general laboratory practice, basic equipment, inventory and sample management

Whilst not essential it may be an advantage if you have experience of:

  • Tissue handling
  • Tissue Procurement
  • Experience using multi-colour flow cytometry
  • Laboratory experience in an industrial, clinical or research setting
  • Experience with mammalian cell culture
  • Familiarity with cell biology workflows

Remuneration & Benefits

The salary for the Clinical Tissue Culture Specialist will be competitive within the Biotechnology and wider Scientific sector with actual salary offered reflecting relevant qualifications and experience as well as performance at interview. In any event we anticipate a salary in the £25,000 to £33,000 range together with an attractive bonus and benefits package.

Application Process

If you would like to join us as Clinical Tissue Culture Specialist at this critical time in our development and you think your skills and experience are a good fit for this role apply with a current CV and we’ll get back to you within a day or two.